Lower Airway Disease in Asthmatics with and without Rhinitis
Anne E Dixon, Danielle M Raymond, Benjamin T Suratt, Lorraine M Bourassa, Charles G Irvin. Lung. New York: Dec 2008. Vol. 186, Iss. 6; pg. 361, 8 pgs
Abstract (Summary)
Study Objectives: The purpose of this study was to determine if asthma with rhinitis and asthma without rhinitis represent distinct forms of disease. Design: We performed a prospective cross-sectional study. Participants: The study included healthy controls, participants with asthma without rhinitis, and participants with both asthma and rhinitis. Interventions: We compared lung function and airway inflammation between the three groups of participants. Results: We recruited 32 participants: 12 normals, 8 asthmatics without rhinitis, and 12 with rhinitis. Compared to asthmatics with rhinitis, asthmatics without rhinitis had more severe airflow limitation (FEV1/FVC = 60.6% [IQR = 22.8] vs. 74.8% [IQR = 7.8] and fewer induced sputum eosinophils (2.8 [IQR = 5.8] and 9.6 [IQR = 23.8], respectively). Sputum interleukin-6 correlated inversely with lung function measured by postbronchodilator FEV1 in the study cohort (Spearman correlation coefficient = -0.55, p <>
Anne E Dixon, Danielle M Raymond, Benjamin T Suratt, Lorraine M Bourassa, Charles G Irvin. Lung. New York: Dec 2008. Vol. 186, Iss. 6; pg. 361, 8 pgs
Abstract (Summary)
Study Objectives: The purpose of this study was to determine if asthma with rhinitis and asthma without rhinitis represent distinct forms of disease. Design: We performed a prospective cross-sectional study. Participants: The study included healthy controls, participants with asthma without rhinitis, and participants with both asthma and rhinitis. Interventions: We compared lung function and airway inflammation between the three groups of participants. Results: We recruited 32 participants: 12 normals, 8 asthmatics without rhinitis, and 12 with rhinitis. Compared to asthmatics with rhinitis, asthmatics without rhinitis had more severe airflow limitation (FEV1/FVC = 60.6% [IQR = 22.8] vs. 74.8% [IQR = 7.8] and fewer induced sputum eosinophils (2.8 [IQR = 5.8] and 9.6 [IQR = 23.8], respectively). Sputum interleukin-6 correlated inversely with lung function measured by postbronchodilator FEV1 in the study cohort (Spearman correlation coefficient = -0.55, p <>
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es hora de dejar d fumar, despues d haber leido el pte articulo, interesante
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